The initial applications of the 18F-labeled FAP-2286-derived imaging agent are illustrated in Figure 7, where Al18F-NOTA-FAP-2286 PET enabled mild imaging of the tumor region in 22RV-1-R/NIH-3T3 co-cultured cell tumor-bearing mice (SUVmax = 0.521 ± 0.096 at 45 min and SUVmax = 0.584 ± 0.103 at 90 min post-injection, Figure 7A,B). Here, FAP is linked to neoplasm.