Also, the UGT1A1 genotype, considering the UGT1A1*28 and/or *6 alleles, is associated with ADE occurrence among irinotecan-treated patients, even if we compare UGT1A1-wild-type and heterozygous patients (UGT1A1*1/*28 or *1/*6 genotypes). This evidence concerns the gene UGT1A1 and acute disseminated encephalomyelitis.