Several studies have shown that the expression level of Viperin is significantly altered in autoimmune diseases such as systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA) and that it exhibits bi-directional immunoregulation in autoimmune diseases, where it may influence the progression of the disease by modulating the immune response [80,81]. This evidence concerns the gene RSAD2 and rheumatoid arthritis.