Zhang et al. (2023) carried out single cell sequencing analysis of T cells in normal cervix, HSIL, and cancer, and proposed a reduction in Th cells and an increase in Treg in HSIL, which progressed to an increase in activation-coupled exhausted CD8 T cells and reduced cytotoxic CD8 T cells in microinvasive cervical cancer [208]. Here, CD8A is linked to cancer.