Emerson et al. [85] transfected 11 cell lines with HEV-1 infectious cDNA clones, including Huh-7, Caco-2, HepG2/C3A, PLC/PRF/5, A549, rat liver cancer cells (BRL3A), human liver cancer cells (Hepa 1–6), porcine kidney cells (PK), porcine testicular cells (ST), human skin fibroblasts (HS27), and African green monkey kidney cells (Vero). Here, HSPG2 is linked to liver cancer.