Moreover, VDAC1 antibodies, as well as metformin, and the specific VDAC1-interacting molecule VBIT-4 that inhibits its oligomerization restored impaired ATP generation and glucose-stimulated insulin secretion in T2DM islets and in db/db mice, maintaining normal glucose tolerance and restored insulin secretion [63]. Here, VDAC1 is linked to type 2 diabetes mellitus.