VDAC1 is overexpressed in cancer [36,56,57], Alzheimer’s disease (AD) [58,59,60], T2DM [61,62,63], autoimmune diseases such as lupus [53], cardiovascular diseases (CVDs) [64,65,66,67,68,69], inflammatory bowel diseases (IBDs) [70], non-alcoholic fatty liver disease (NAFLD) [71], COVID-19 [72,73], and others. The gene discussed is VDAC1; the disease is metabolic dysfunction-associated steatotic liver disease.