Furthermore, cascade testing for high Lp(a) levels is recommended in the settings of FH, family history of elevated Lp(a), personal or family history of premature ASCVD, and personal history of calcific valvular aortic stenosis and recurrent or progressive ASCVD, despite optimal lipid-lowering therapy [3,6,20]. The gene discussed is LPA; the disease is aortic valve stenosis.