AKT1 and Cerebral ischemia: Furthermore, the Phosphatidylinositol 3-kinase/Akt (PI3K/Akt) signaling pathway is a central regulator of cell survival, proliferation, and metabolism; its activation, often measured by the phosphorylation of Akt (p-Akt), is known to inhibit apoptosis and promote recovery after cerebral ischemia [32,33].