The search aimed to identify relevant studies published between 2005 and 2024 and employed the following search terms: “Alcohol-induced liver disease and Phytochemicals”, “Alcohol-induced liver disease and inflammation”; “Alcohol-induced liver disease and cGAS-STING signaling”; “Alcohol-induced liver disease and NLRP3 inflammasomes”; “Alcohol-induced liver disease and NF-κB signaling”; “Alcohol-induced liver disease and MAPK signaling”; and “Alcohol-induced liver disease and JAK-STAT signaling”. This evidence concerns the gene CGAS and alcohol dependence.