The correlation coefficients (Pearson’s r) and p values for various factors (age, years of illness, therapy, and other clinical variables) against two key health indicators in HIV patients, CD4 count (cells/mm3) and HIV-1 RNA viral load (copies/mL), showed that for patients with mono-HIV infection, there are weak correlations between clinical parameters and immune response, underlining the importance of other factors (like ongoing treatment adherence and regimen) in managing HIV infection. Here, CD4 is linked to HIV infectious disease.