They include galectin-3 [86], a mediator of myocardial fibrosis; myeloperoxidase (MPO) [87], an indicator of oxidative stress and neutrophil activation; growth differentiation factor-15 (GDF-15) [88], associated with cellular stress and mitochondrial dysfunction; and microRNA (miRNA) molecules [89,90,91], which regulate gene expression and may reflect adaptive or maladaptive responses of the myocardium to treatment. This evidence concerns the gene GDF15 and Myocardial fibrosis.