We included randomized control trials (RCTs) using any pharmacological drugs (e.g., insulin sensitizers, anti-androgens, anti-obesity drugs, oral contraceptive pills, ovulation induction drugs, etc.)or non-pharmacological intervention (e.g., yoga, diet, herbal supplements, etc.)with Indian PCOS patients for improving common manifestations of PCOS and written in the English language. The gene discussed is INS; the disease is obesity due to melanocortin 4 receptor deficiency.