We included randomized control trials (RCTs) using any pharmacological drugs (e.g., insulin sensitizers, anti-androgens, anti-obesity drugs, oral contraceptive pills, ovulation induction drugs, etc.)or non-pharmacological intervention (e.g., yoga, diet, herbal supplements, etc.)with Indian PCOS patients for improving common manifestations of PCOS and written in the English language. This evidence concerns the gene INS and polycystic ovary syndrome.