Although active lifestyle modifications such as restricted diet and exercise are the primary interventions to control weight, if needed, anti-obesity drugs such as glucagon-like-peptide-1 (GLP-1) receptor agonist (liraglutide, semaglutide, exenatide) and orlistat are being prescribed internationally for weight management in adult PCOS patients. The gene discussed is GLP1R; the disease is obesity due to melanocortin 4 receptor deficiency.