For example, manic states in BD are characterized by elevated levels of acute-phase proteins, including interleukin (IL), tumor necrosis factor-α (TNF-α), and interferon-γ (IFN-γ) [69], as well as haptoglobin, fibrinogen, and C-reactive protein (CRP), with a particularly pronounced increase in CRP during manic phases [67,70]. This evidence concerns the gene TNF and Behcet disease.