PRKG1 and neuropathy: Considering that FBP administration increases ADO blood levels by approximately 50%, reaching 1.5 μM in a model of carrageenan inflammatory pain [21], and ADO induces analgesia in CCI neuropathy by activating adenosine A1 and A2A receptors (present data), it was verified whether FBP also activates the NO/cGMP/PKG/K+ATP signaling pathway to induce analgesia (Figure 5).