PRKG1 and neuropathic pain: There are examples of drugs in clinical use (e.g., metamizole, diclofenac, and morphine) [65,66,67] and in the pre-clinical phase (e.g., diosmin, kaurenoic acid, nitroxyl, indomethacin, loperamide, and tingenone) [45,56,68,69,70,71], which share the NO/cGMP/PKG/K+ATP mechanism of action, highlighting the importance of this signaling pathway in analgesia in inflammatory and neuropathic pain.