BNIP3 and gastric cancer: Additionally, studies conducted both in vitro and in vivo have demonstrated that methionine deficiency reduces the expression of long non-coding RNA (lncRNA) PVT1 and influences its interaction with DNMT1, leading to the demethylation of the promoter of BCL2 interacting protein 3 (BNIP3), thereby inhibiting the proliferation of gastric cancer cells [62].