ESCC cells can uptake large amounts of methionine to synthesize SAM, which in turn stabilizes the mRNA and enhances the protein expression of the oncogene NR4A2 via the “METTL3-RNA m6A-IGF2BP2” axis, ultimately facilitating ESCC progression [27]. The gene discussed is IGF2BP2; the disease is esophageal squamous cell carcinoma.