In this context, considering the correlation between oral health and inflammation as well as systematic disease, including AD, the present study is designed to estimate the impact of quercetin and apigenin on selected pro-inflammatory cytokines such as interleukin-1β (IL-1β), interleukin-6 (IL-6), interleukin-8 (IL-8), interleukin-15 (IL-15), and tumour necrosis factor (TNF-α) secreted by gingival fibroblast during bacterial and viral infections. The gene discussed is IL15; the disease is viral infectious disease.