It is worth noting that inflammatory pathways, such as the NF kappa B, chemokine, NOD-like receptor, TNF, and IL-17 signaling pathways, as well as infection-related pathways such as human cytomegalovirus infection, Kaposi sarcoma-associated herpesvirus infection, and legionellosis, play an important role during this process. The gene discussed is TNF; the disease is legionellosis.