KCNA5, PTGS2, and TNF were found to significantly participate in ascorbate and aldarate metabolism, graft-versus-host disease, the NOD-like receptor signaling pathway, olfactory transduction, pentose and glucuronate interconversions, porphyrin and chlorophyll metabolism, prion diseases, starch and sucrose metabolism, and type I diabetes mellitus (Figure 7A–C). The gene discussed is TNF; the disease is graft versus host disease.