PTGS2 and infection: When infection or tissue damage occurs in the body, the activity of PTGS2 increases, resulting in the synthesis of more prostaglandins, particularly PGE2, which causes vasodilation, stimulates nerve endings and raises body temperature through the action of the hypothalamic thermoregulatory centre, This leads to fever, which can be reduced by inhibiting the activity of PTGS2 and reducing the synthesis of PGE2, which in turn reduces inflammation and lowers body temperature, thus inhibiting PTGS2 can play an “antipyretic” role [21,22].