Compared with the control group, the serum and CSF levels of PGE2, cAMP, CRH and AVP in the rats in the model group were significantly higher (p < 0.01), and the serum Ca2+ content was increased (p < 0.01), while the CSF Ca2+ content was slightly decreased (p < 0.01), and all of them were found to be improved after administration of the corresponding drugs, but the effect of BHT was significantly better than that of gypsum, indicating that the fever in the LPS-induced rat fever model is closely related to the above relevant factors (Figure 4). The gene discussed is CRH; the disease is Fever.