However, AVP can only partially block or reduce the lipopolysaccharide (LPS)-induced fever response [25], whereas prostaglandin E2 (PGE2) is an important biologically active substance produced and released in vivo mainly by stimuli such as inflammatory responses, infection, and tissue injury [26,27,28]; PGE2 can affect thermoregulation and fever through a variety of pathways, including inhibition of thermoreceptor activity [29], which can lead the thermoregulatory centre to mistakenly believe that body temperature has decreased and cause fever [30]. This evidence concerns the gene AVP and infection.