Recently, Pavlov and coworkers [14] also demonstrated in a murine model the involvement of Panx1 channels in Autosomal Dominant Polycystic Kidney Disease (ADPKD), a monogenic disorder caused by PDK1 and/or PDK2 mutations, which result in the development of multiple cysts overexpressing Panx1 channels across the nephron [15]. Here, PDK1 is linked to autosomal dominant polycystic kidney disease.