Given that BChE contributes to ACh hydrolysis and has been implicated in amyloid pathology, as it is found in mature amyloid-β plaques [13] and may contribute to amyloid-β aggregation by facilitating peptide fibrillization [25], interest in dual AChE/BChE inhibitors has grown as a potential strategy for AD treatment. The gene discussed is ACHE; the disease is Alzheimer disease.