Since CHCHD4 and its protein substrates are emerging as a new class of proteins associated with various pathologies, it is of particular importance to define the role of the CHCHD4-dependent mitochondrial import pathway in health and disease, including mitochondrial disorders, neurodegeneration, and cancer [10,12,13,14,15,16,17,18,19,20,21,22,23,24,25,26,27,28,29,30,31,32,33,34,35,36,37,38]. Here, CHCHD4 is linked to cancer.