STYK1 and Insulin resistance: However, in Nok-treated db/db mice, blood glucose levels significantly decreased after insulin injection, with a minimum value reached at 60 min, and AUC values significantly lower than those of the untreated db/db model mice, comparable to the Metformin-treated group (Figure 2C,D), suggesting that Nok markedly improves insulin resistance in db/db diabetic mice.