Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis of the top 50 up-regulated genes identified enrichment in pathways related to extracellular matrix (ECM)–receptor interaction, focal adhesion, cell adhesion molecules, Notch signaling, NF-κB signaling, Jak-STAT signaling, and choline metabolism in cancer (Figure 4A). The gene discussed is NFKB1; the disease is cancer.