Research studies to evaluate the effects of metal complexing agents such as NOTA- and NODAGA-conjugated α-MSH peptides for melanoma targeting and clearance have also been investigated by our research team considering the ability of tridentate NOTA and NODAGA to coordinate [99mTc(CO)3]+ tricarbonyl core in a facial fashion via three N atoms [105]. This evidence concerns the gene STAMBP and melanoma.