Among these promising radiolabeled cyclic α-MSH peptides, [[68Ga]Ga-1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid-Gly-Gly-Nle-c[Asp-His-DPhe-Arg-Trp-Lys]-CONH2] ([[68Ga]Ga-DOTA-GGNle-CycMSHhex]) has been able to produce remarkable PET images of melanoma metastases in the brain, lung, connective tissue, and intestines of melanoma patients by targeting MC1Rs [93], demonstrating the clinical potential of MC1R-targeted peptide radiopharmaceuticals for melanoma imaging and therapy. This evidence concerns the gene MC1R and melanoma.