Taking advantage of the unique opportunity to target more than one biomarker on the surfaces of prostate cancer, Liu and co-workers have reported the synthesis of heterodimeric regulatory peptide probes of RGD/BBN conjugates for GRPR/αvβ3 dual receptor imaging, in which they focused upon PC-3 tumor uptake in nude mice with [68Ga-] or [64Cu]-radiolabeled [NOTA-RGD-BBN(7-14)NH2] (Figure 6), where the RGD and BBN targeting motifs are linked by a glutamic acid [64,65]. The gene discussed is GRPR; the disease is prostate cancer.