Upon treatment with 25 mg/kg of compound 12, there was an increasing trend in the infiltration of total immune cells (CD45+ cells) (Figure 4C), and the tumor infiltration of total TAMs, TAMs with the M2-liketumor-promoting phenotype (CD206+ TAMs), and immunosuppression TAMs (ARG1+ TAMs) in CD45+ cells was significantly reduced (Figure 4D–F), accompanied by the marginal upregulation of TAMs with the M1-like phenotype (CD86+ TAMs, MHC II+ TAMs) (Figure S3A,B). This evidence concerns the gene ARG1 and neoplasm.