The genotypic frequencies of visfatin SNPs, including rs2302559 (OD: 18.222; 95% CI 10.228–32.466; p-value < 0.001) and rs1215113036 (OD: 129.40; 95% CI 44.576–375.693; p-value < 0.001), were significantly associated with MetS. This evidence concerns the gene NAMPT and metabolic syndrome.