Serum concentrations of BAFF, APRIL, and other cytokines, including IL-4, IL-6, IL-10, and IL-13, can be implicated in the differentiation of B-cell lineages [32], while significant increases in BAFF, APRIL, IL-4, and IL-6 were observed in patients with ANCA-vasculitis [33]. The gene discussed is TNFSF13B; the disease is vasculitis.