Research has demonstrated that VEGF initiates and sustains pathological neovascularization, and its inhibition via VEGF receptor 1 (VEGFR-1 and Flt) or VEGF receptor 2 (VEGFR-2, Flk, and KDR) signaling effectively curtails neovascularization and tumor growth [13]. Here, FLT1 is linked to neoplasm.