SHBG and Insulin resistance: Recently, we estimated empirical optimal cut-off values for SHBG levels were ≤41.5 nmol/L, which is typical for insulin resistance in young Caucasian women with PCOS (area under ROC curve [AUC] 0.71, sensitivity [Se] 61.1%, specificity [Sp] 71.6%, positive predictive value [PPV] 70.7%, and negative predictive value [NPV] 62.1%) [22].