Therefore, this study aimed to estimate the cut-off value for the TyG index discriminating insulin resistance based on the previously established cut-offs for HOMA-IR (Homeostatic Model Assessment for Insulin Resistance) and serum level of SHBG (sex hormone-binding globulin) in Caucasian women with polycystic ovary syndrome (PCOS). The gene discussed is SHBG; the disease is Insulin resistance.