Immunohistochemistry (IHC) results revealed bladder biopsy with a high-grade muscle invasive urothelial carcinoma with areas of conventional and signet ring cell morphology: GATA 3 positive diffuse in tumor cells, CK 20 focal positive in tumor cells, CK5/6, P63 and CDX2 negative in tumor cells; rectal wall biopsy with same characteristics for tumor cells but with positive internal control markers for CK 20, CDX2 in colonic epithelium(Figure 4A–F). This evidence concerns the gene CDX2 and neoplasm.