CLDN4 and renal carcinoma: Through qRT-PCR analysis, the mRNA expression profiles of AMH, CLDN4, HAMP, SEMA3A, PLXNB3, UCN, PYCR1, and TEK showed marked upregulation in 786-O and Caki-1 renal carcinoma cell lines relative to the HK-2 normal renal tubular cell line (Figure 8A–H).