Finally, we conducted a prognostic signature comprising eight IMRGs, including UCN, HAMP, SEMA3A, AMH, PYCR1, PLXNB3, CLDN4, and TEK, highlighting a strong association between immune metabolism and ccRCC pathogenesis (Figure 2C, Table 1). Here, CLDN4 is linked to nonpapillary renal cell carcinoma.