Also of interest is dimethylargininase (Ddah2), a zinc protein involved in nitric oxide synthase regulation, which is elevated in neurons displaying cytoskeletal abnormalities and oxidative stress in Alzheimer’s disease (AD) [93]; it was also increased in APP/PS1 and decreased significantly following CBDA. The gene discussed is DDAH2; the disease is early-onset autosomal dominant Alzheimer disease.