By analysing IL1β, IL10, IL18, TNF-α, TLR4, GATA3, and CD68 expression in 50% of PCa HHV-infected FFPE with an elevated inflammation index (61.8%/21), we detected hyper-expressed levels of IL1β, IL18, and TNF-α in the tumour microenvironment. Here, TLR4 is linked to posterior cortical atrophy.