ACOX2 and breast cancer: Similar observations were made in other tumor types, including hepatocellular carcinoma and breast cancer, albeit expressing either NAC1 or ACOX2, demonstrating that the overexpression of NAC1 or the low expression of ACOX2 was correlated with shorter disease-free survival in these tumors [20,33,34,35,51], thus both factors might be mutually correlated to affect oncologic outcomes across tumor types.