Furthermore, recent studies indicated the therapeutic potential of astragaloside IV (derived from Radix Astragali) and icaritin in the treatment of an in vitro model of Alzheimer’s disease (AD) in HT22 hippocampal cells through their modulation of brain-derived neurotrophic factor (BDNF) and apoptotic signaling. This evidence concerns the gene BDNF and early-onset autosomal dominant Alzheimer disease.