BDNF and Alzheimer disease: Some of the agents applied, such as ZN-015 (a coumarin derivative), VB-030, and VB-037 (quinoline derivatives), demonstrated significant neuroprotective effects, including a reduction in AD-like markers such as Bax and caspase-1/6, while also increasing the ratios of BDNF/proBDNF and TrkB/pTrkB.