Tan IIA, the primary constituent of traditional Chinese medicine Danshen, showed anti-inflammatory, antioxidant, and anti-apoptotic properties, suggesting that the upregulation of the CREB-BDNF-TrkB signaling pathway in the hippocampus may attenuate underlying AD pathophysiological mechanisms [173], as shown in Table 2. This evidence concerns the gene CREB1 and Alzheimer disease.