Furthermore, Cheon and colleagues [230] investigated heat-killed Lactobacillus plantarum 200655, which revealed its neuroprotective effect against H2O2-treated SH-SY5Y cells by increasing the levels of BDNF and tyrosine hydroxylase and preventing apoptosis by enhancing the ratio of Bcl-2/Bax and decreasing caspase-3, which suggested that probiotics may prevent neurodegenerative diseases. The gene discussed is BDNF; the disease is neurodegenerative disease.