Bilge and colleagues [216] applied a stereotaxic PD model with rotenone in rats to estimate the neuroprotective action of agmatine, an endogenous decarboxylation product of l-arginine, which was found to mitigate motor impairments, decrease striatal neuronal death, and restore the BDNF/CREB survival pathway. This evidence concerns the gene BDNF and Parkinson disease.