In this context, the present randomized controlled trial (RCT) aimed to assess the effect of the topical administration on the oral mucosa of said composition delivered via a daily toothpaste on salivary cytokines IL-1ß, TNF-α and IL-4 in periodontally healthy normal and overweight/pre-obesity patients as the primary objective. This evidence concerns the gene IL1B and obesity due to melanocortin 4 receptor deficiency.