HIF1A and hepatocellular carcinoma: Hypoxic-inducible factor (HIF)-1α was significantly expressed in HCC Luc-SK-Hep1 cells at low oxygen (2% O2) but not at normal oxygen (20% O2), as shown in Figure 2A. Treatment with antibodies (human anti-IL-6; human anti-MCP1) in the cell culture under hypoxia resulted in a significant inhibition of HIF-1α expression in the cells (Figure 2A; * p < 0.05; *** p < 0.0001).