Tumor metastasis in mice derived from the intra-tail vein injection of HCC cells was significantly inhibited compared to that in untreated mice when intraperitoneally injected with anti-IL-6 or anti-MCP1 antibodies, due to the inhibitory effect of N-cadherin expression in tumors in mouse liver tissue (Figure 3 and Figure 4). Here, IL6 is linked to hepatocellular carcinoma.