When co-cultured with HCC cells under hypoxia, CD56+dim NK cells were also significantly increased, and the expression of NK-activating receptors NKG2D and NKp44 on the surface of NK cells was enhanced (Figure 6A–D; CD56+dim: untreated 8.59%, anti-IL-6 10.77%, anti-MCP1 13.06%, Comb 15.80%; NKG2D+: untreated 47.47%, anti-IL-6 53.96%, anti-MCP1 54.64%, Comb 54.34%; NKp44+: untreated 8.69%, anti-IL-6 11.30%, anti-MCP1 11.95%, Comb 17.66%; * p < 0.05; ** p < 0.001; *** p < 0.0001). This evidence concerns the gene NCR2 and hepatocellular carcinoma.