It was found that the deletion of PGGT1B significantly aggravated the psoriasis-like lesions in mice, which was mainly due to the fact that macrophages with PGGT1B deletion were more likely to migrate to the epidermis during psoriasis, leading to the activation of Cdc42, NF-κB signaling pathway, and NLRP3 inflammatory bodies. The gene discussed is NLRP3; the disease is psoriasis.