In addition, loricrin in the cuticle of the two genotypes of mice decreased, and the decreasing trend in the cko group was more significant than that in the wt group (Figure 1F, p < 0.05), which indicates that in the IMQ-induced psoriasis model, myeloid PGGT1B deficiency promoted the proliferation of keratinocytes and inhibited their differentiation. This evidence concerns the gene PGGT1B and psoriasis.