It was found that the deletion of PGGT1B significantly aggravated the psoriasis-like lesions in mice, which was mainly due to the fact that macrophages with PGGT1B deletion were more likely to migrate to the epidermis during psoriasis, leading to the activation of Cdc42, NF-κB signaling pathway, and NLRP3 inflammatory bodies. Here, PGGT1B is linked to psoriasis.