AKT1 and cancer: For example, other G protein-coupled receptors (GPCRs) implicated in cancer metastasis, such as CXC receptor 4 (Gi-coupled) and protease-activated receptor-1 (Gq-coupled), often activate similar mitogen-activated protein kinase (MAPK) and PI3 kinase/protein kinase B (PI3K/AKT) pathways and may also be involved in the observed cellular phenotypes [38,39,40].