Then, to examine whether the impact of Gα13 on SOD2 protein expression might be mediated through SOD2 mRNA expression in prostate cancer tissue, we first analyzed three independent RNA sequencing datasets from TCGA-PRAD [42], the German Cancer Research Center (DKFZ, early-onset prostate cancer) [43] and the SU2C-PCF project (metastatic, castration-resistant prostate cancer) [44] on the cBioPortal website [37,45]. Here, SOD2 is linked to Familial prostate cancer.