These results indicate that Gal-3 more effectively stimulates ERK phosphorylation in A375 EVCtrl cells compared to A375 GCNT2OE cells, suggesting that the presence of GCNT2/I-branching modulates the intracellular response of the MAPK signaling axis to the exogenous binding of Gal-3 to melanoma cells. The gene discussed is GCNT2; the disease is melanoma.