While increased expression of β1,6GlcNAc-branched N-glycans, synthesized by β1,6-acetylglucosaminyltransferase V (MGAT5, also known as GnT-V), has been consistently linked to enhanced galectin binding and tumor progression [7,10], our study reveals a contrasting effect of β1,6 branching at the level of poly-LacNAc chains. The gene discussed is MGAT5; the disease is neoplasm.