The role of IL-37 has been investigated in several autoimmune diseases, including Guillain–Barré syndrome [17], Crohn’s disease [18], Graves’ disease [19], psoriasis [20], rheumatoid arthritis [21], systemic lupus erythematosus [22], and ankylosing spondylitis [23]. This evidence concerns the gene IL37 and rheumatoid arthritis.