The serum levels of the biomarkers exhibited the following differences: a significant increase in ATX (112.07 ± 50.0 vs. 93.54 ± 27.2 ng/mL, p = 0.003), GDF-15 (1.34 ± 1.4; Q1: 0.64; Q3: 1.5 vs. 0.71 ± 0.5; Q1: 0.32; Q3: 0.94 ng/mL, p < 0.001), and TM (7.76 ± 4.0 vs. 6.3 ± 1.9 ng/mL, p = 0.005) were observed in the AS as compared to the control group. The gene discussed is ENPP2; the disease is aortic valve stenosis.