AFP and neoplasm: Studies investigating the effects of tumor-derived AFP (tAFP) on lipid metabolism in DCs have shown that it downregulates several key genes involved in fatty acid metabolism, including pyruvate dehydrogenase, ATP-citrate lyase, acetyl-CoA carboxylase, fatty acid synthase, lipoprotein lipase, CD36, and carnitine-acylcarnitine translocator.