TYR and acne: Tretinoin (all-trans retinoic acid) interferes with melanogenesis and melanocyte activity by transcriptionally regulating tyrosinase [9] Glycyrrhiza glabra extracts, containing active components such as glycyrrhizin, triterpene saponins, flavonoids, and glabridin, exert skin-whitening, anti-aging, anti-inflammatory, anti-acne, and photoprotective effects, primarily through antioxidant activity, the inhibition of tyrosinase, and UVB-induced melanogenesis [10].