and promoting different and opposing cell responses, among them plasminogen activator inhibitor-1 (PAI-1), elevated in arterial plaques; vessel fibrosis; arteriosclerosis; and thrombosis, inhibitor of fibrinolysis [10,11], as well as proteins promoting epithelial–mesenchymal transition such as occludin, E-cadherin, or snail; proteins inducing cell growth and survival in cancer such as the GTP-binding protein RAD; and a protein inhibiting cell growth c-Myc, p21. Here, SERPINE1 is linked to cancer.