HMOX1 and intracerebral hemorrhage: In experimental models of intracerebral hemorrhage, its overexpression induces a proinflammatory response in microglia and disrupts the balance of iron metabolism [47,48], while in astrocytes or in a subarachnoid hemorrhage mouse model HMOX-1 overexpression provides neuroprotective effects against intracerebral hemorrhage [49,50] or against Dengue virus-induced vascular endothelial dysfunction and leakage [51].