Regarding plasma AFP, ROC analysis demonstrated its ability to differentiate HCC from healthy controls, with an AUC of 0.83 (95% CI: 0.815 to 0.925, p < 0.0001), with a sensitivity of 74% and specificity of 94% at a cutoff > 27.5 ng/mL (Figure 5D). The gene discussed is AFP; the disease is hepatocellular carcinoma.