Crucial AD-associated genes were identified in each cell type, including RGS1, GRIA1, GRIA3, GRIA4, DLGAP1, MSN, CHL1, DCN, LPAR1, EGFR, GRM5, CAMK2A, APOE, AQP4, GFAP, and CD44, showing potential involvement in AD. This evidence concerns the gene GRM5 and Alzheimer disease.