We further present the expression patterns of the same gene set in an integrated analysis of published AD organoid single-cell sequencing data [19], which demonstrated conserved expression changes for several genes (CD44, CHL1, MSN, RGS7, GRIA1, CAMK2A, DLGAP1, GFAP) between human brain tissue and organoid models, while also identifying model-specific differences (Figure 6D). Here, CHL1 is linked to Alzheimer disease.