NFKB1 and cerebrotendinous xanthomatosis: Western blotting results showed that, while the CTX group significantly up-regulated the ratio of the p-p65/p65 protein in mice kidneys and brains (## p < 0.05 or ### p < 0.001), the ICA group inhibited the phosphorylation of p65, thus confirming our conjecture that ICA may exert a protective effect against CTX-induced RE by inhibiting the NF-κB signaling pathway.