For instance, Zhang et al. reported that cytokine-activated CD8+ T cell-derived EVs (caCD8-EVs) exhibit robust cytotoxicity against diverse cancer cells in vitro, mediated by cytotoxic proteins (granzyme B and perforin) and interferon gamma (IFNγ), synergistically inducing tumor cell apoptosis [76]. The gene discussed is IFNG; the disease is cancer.